Risk Estimation for Recurrent Clostridium difficile Infection Based on Clinical Factors

Risk estimation for recurrent Clostridium difficile infection based on clinical factors.

BACKGROUND The incidence of Clostridium difficile infection (CDI) has risen dramatically during the last decade. Although patients respond well to medical therapy such as vancomycin, 20%-30% of patients treated suffer a recurrence of CDI. METHODS We developed a simple/practical scoring rule (logistic regression model) for recurrent CDI using data from 2 large phase 3 clinical trials. Seventy-...

Risk Factors for Recurrent Clostridium difficile Infection in Pediatric Inpatients.

OBJECTIVE The purpose of this study was to identify the risk factors during the incident Clostridium difficile infection (CDI) episode, associated with developing recurrent CDI within 60 days, among hospitalized children that may be amenable to intervention. METHODS This was a retrospective cohort study of pediatric patients hospitalized at a freestanding children's hospital from January 1, 2...

Risk Factors for Recurrent Pedatric Community Associated Clostridium difficile Infection

Risk factors for early recurrent Clostridium difficile-associated diarrhea.

Recurrence is a common sequela of Clostridium difficile-associated diarrhea (CDD) and may increase morbidity, costs, and treatment-related antimicrobial resistance. Because recurrent CDD (RCDD) frequently occurs very soon after an initial episode, our goal was to determine the risk factors for early RCDD (occurring < or = 45 days after the initial episode). We conducted a case-control study, co...

Treatment Strategies for Recurrent Clostridium difficile Infection.

BACKGROUND Recurrent Clostridium difficile infection represents a major clinical challenge. Treatment is often based on empiric selection from relatively few options supported by limited clinical evidence. OBJECTIVE To review and evaluate the literature on therapeutic alternatives for recurrent C. difficile infection. DATA SOURCES The MEDLINE, PubMed, Embase, and Cochrane databases were sea...